Sober-Living

A recent review by Aspromonte et al.217 has summarized a comprehensive modulation of cardiac CYP in patients with HF. In general, cardiac CYP1B and CYP2A, CYP2B, CYP2J, CYP4A and CYP11 mRNA levels and related enzyme activities are usually increased in HF217,218. On the other hand, HF plays an important role in the down-regulation of hepatic CYP involved in drug metabolism through several mechanisms which include hepatocellular damage, hypoxia, elevated levels of pro-inflammatory cytokines, and increased production of heme oxygenase-1219....

Even if the person survives, an alcohol overdose like this can lead to long-lasting brain damage. As blood alcohol concentration (BAC) increases, so does the effect of alcohol—as well as the risk of harm. Even small increases in BAC can decrease motor coordination, make a person feel sick, and cloud judgment. More than 2,200 people die from alcohol poisoning each year, an average of six people per day, according to the Centers for Disease Control and Prevention (CDC)....